Astrazeneca Vaccine Update: Know How Rare Is AstraZeneca Coronavirus Vaccine Blood Clots risk

Astrazeneca Vaccine Update: Know How Rare Is AstraZeneca Coronavirus Vaccine Blood Clots risk

Highlights:

  • People over 50 years of age are weighing the benefits of having an AstraZeneca vaccine.
  • There were reports of blood clots after the AstraZeneca vaccine was exposed
  • It is a relief, blood clotting is very rare after the AstraZeneca vaccine.

Melbourne
With the spread of the COVID-19 pandemic once again on the rise, people over the age of 50 are weighing the benefits of getting a vaccine against the virus with the rare risk of blood clots from the AstraZeneca vaccine. The clotting disease, called vaccine-induced thrombotic thrombocytopenia (VITT) or thrombocytopenia with thrombocytopenia syndrome (TTS), has been reported since the first reports of blood clots following the AstraZeneca vaccine exposure in March 2021. Our understanding has increased.

Now we know how to diagnose and treat it, so we are likely to see better results for patients with this condition. How common and deadly is it? It’s a relief, blood clots after the AstraZeneca vaccine are very rare. So far, 2.1 million doses of AstraZeneca vaccine have been given in Australia, of which 24 cases of TTS have been reported. So the risk of TTS is about one in 88,000. These figures are similar to those collected in the UK, Europe, the Middle East and Canada in this regard.

What exactly is blood clotting?
Although early reports from Europe indicated that about 20 percent of TTS cases were fatal, to date in Australia, one in 24 TTS cases has been fatal. What exactly is blood clotting with thrombocytopenia syndrome (platelet number)? Although we do not yet have a complete explanation, it appears that the AstraZeneca vaccine can activate platelets, which are small cells in our blood and are important for thickening the blood that prevents bleeding. In some people, these active platelets can release a protein, called platelet factor 4 (PF4), which binds to the AstraZeneca vaccine.

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It is believed that PF4 can induce the immune system to activate more platelets, causing them to stick together and thereby reduce their numbers. This action is quite different from the normal process by which blood clots are formed. While TTS appears to be the result of an irregular immune response, existing evidence suggests that people who have had a heart attack, stroke, a clot in the lungs, or regularly take blood-thinning medications have no increased risk of TTS. it occurs.

Diagnostic tests and guidelines play a major role in identifying and treating cases of TTS. In most cases, patients have low platelet count, blood clotting, and antibodies against PF4. Many of these tests can be done quickly. Treatment can now begin immediately, with blood thinning medications and immune system lowering drugs. By 20 May when the latest vaccine safety report was released, 21 of the 24 Australians with TTS had recovered and were discharged from hospital and two were stable and recovering in hospital.

It is very common to have some side effects after any vaccine.
So what side effects are common, and can clot signify freezing? It is quite normal to have some side effects after any vaccine. In the case of the AstraZeneca vaccine, it occurs in the first two days after vaccination and includes headache fever (chills), muscle and joint pain, nausea, pain at the site of the injection, which is cured by simple measures like paracetamol. is. Similarly, symptoms that may indicate TTS after receiving AstraZeneca vaccine include: persistent or severe headache, blurred or double vision, difficulty breathing, severe pain in the abdomen, back, or chest, swelling, redness, leg pain, unusual bleeding or bruising. .

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If you experience any of these symptoms four to 30 days after your vaccination, seek medical advice immediately. Balancing the risks and benefits The risk of TTS is very rare, some people will be worried and would like to discuss them with their doctor. However, given the ongoing risk of COVID outbreaks in Australia and their potentially fatal consequences, as well as its potentially serious long-term effects, for most people, the benefits of vaccination against COVID far outweigh the potential risks.

Authors: Karlhenge Peter, Baker Heart & Diabetes Institute and James McFadden, Baker Heart & Diabetes Institute

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AstraZeneca’s vaccine increases blood clotting risk

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